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Organic compounds that contain a carboxyl group bonded to an organic functional group; carboxyl groups consist of a carbonyl group bonded to a hydroxy group. Includes compounds that are derived from carboxylic acids.
Trimebutine maleate is the maleate salt form of trimebutine which is a spasmolytic agent that regulates intestinal and colonic motility and relieves abdominal pain with antimuscarinic and weak mu opioid agonist effects
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Dimethindene maleate is a selective antagonist of histamine H1 and exhibits antihistamine effects It suppresses the cromakalim-induced/glibenclamide-sensitive K currents in a concentration-dependent and reversible manner
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Also available in 5 mg, 10 mg, 25 mg, 50 mg, 100 mg and bulk. Please contact Fisher for quotes. Fenclozine Maleate (S 1429) is a potential histamine H1 receptor antagonist , which can be used to study fever, inflammation and pain. Purity 98.47%
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Zamifenacin fumarate is the fumarate salt of zamifenacin (UK-76654), a gut-selective muscarinic M3 receptor antagonist used in research to study gastrointestinal motility. It is provided as a high-purity solid for use in in vitro and in vivo pharmacology studies targeting colonic motility.
Potent gut-selective muscarinic M3 receptor antagonist that reduces colonic motility.
High purity suitable for research applications (99.0%).
Solid, white to off-white form for convenient handling and dosing.
Molecular weight 531.60 g/mol, molecular formula C31H33NO7.
Recommended storage at 4°C; in solution, -80°C for long-term stability.
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Tegaserod maleate is an orally active serotonin receptor 4 (HTR4; 5-HT4R) agonist and a 5-HT2B receptor antagonist. This compound induces tumor cell apoptosis, attenuates PI3K/Akt/mTOR signaling, and reduces S6 phosphorylation. It demonstrates anti-tumor activity and is being investigated for its potential in irritable bowel syndrome (IBS) research.
Orally active serotonin receptor 4 (HTR4; 5-HT4R) agonist
5-HT2B receptor antagonist
Induces tumor cell apoptosis
Attenuates PI3K/Akt/mTOR signaling
Reduces S6 phosphorylation
Demonstrates anti-tumor activity
Potential for irritable bowel syndrome (IBS) research
For research use only
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Edonerpic maleate is a novel neurotrophic agent that inhibits amyloid-β peptides (Aβ). It has been shown to preserve cortical neurons in the presence of Aβ(1-42) and prevent oxidative stress-induced neuronal death.
Prevents oxidative stress-induced neuronal death.
Almost completely prevents GSH reduction.
Significantly increases neurite length in hippocampal slices.
Ameliorates deficits in adult neurogenesis and spatial memory in rats.
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U-99194 maleate is a selective, potent dopamine D3 receptor antagonist with a Kᵢ of 160 nM. It inhibits the activation of the D3 receptor mediated by endogenously released dopamine or exogenous D3 agonists. This compound can be used for the study of dopamine D3 receptor-mediated motor disorders, particularly kinetic tremors.
Selective, potent dopamine D3 receptor antagonist
Inhibits activation of D3 receptor
Abrogates the IPSC-suppressive effect of D3 agonists
Significantly suppresses Nicotine-induced tremor in mice
Useful for studying dopamine D3 receptor-mediated motor disorders
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Potent, selective and non-competitive NMDA receptor antagonist (Ki = 30.5 nM); acts at the NMDA receptor-operated ion channel as an open channel blocker, preventing Ca2+ flux
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Ro 25-6981 Maleate is a potent, selective, and activity-dependent NR2B subunit-specific NMDA receptor antagonist. It demonstrates anticonvulsant and anti-parkinsonian activity and has potential for research into Parkinson's disease.
Potent, selective, and activity-dependent NR2B subunit-specific NMDA receptor antagonist
Demonstrates anticonvulsant activity
Demonstrates anti-parkinsonian activity
Potential for Parkinson's disease research
Induces contraversive rotations in 6-OHDA-lesioned rats
Exhibits age- and activation-dependent anticonvulsant action
Shows analgesic effects on incision pain in rats
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